In many cancer types, intratumoural hypoxia is linked to increased expression and activity of the transcription factor hypoxia-inducible factor (HIF-1 alpha), which is associated with poor patient prognosis. This increased the interest in HIF-1 alpha as a cancer drug target. Further, HIF-1 alpha a has also a central role in the adaptive cellular programme responding to hypoxia in normal tissues. Many of the HIF-1 alpha-regulated genes encode enzymes of metabolic pathways.

Therefore, studying the link and the feedback mechanisms between metabolism and HIF-1 alpha. is of major importance to find new and specific therapeutic strategies

Aiba, R. S. B., Dimova, E. Y., Gorlach, A., and Kietzmann, T

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